10.1021/ol500173y.s001 Danielle S. Meador Danielle S. Meador David A. Spivak David A. Spivak Absolute Configuration Determination Using Enantiomeric Pairs of Molecularly Imprinted Polymers American Chemical Society 2014 HPLC capacity factors DuoMIP Absolute Configuration Determination binding geometry AC Molecularly Imprinted PolymersA Enantiomeric Pairs enantiomeric pair γ factor 2014-03-07 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Absolute_Configuration_Determination_Using_Enantiomeric_Pairs_of_Molecularly_Imprinted_Polymers/2317069 A new method for determination of absolute configuration (AC) is demonstrated using an enantiomeric pair of molecularly imprinted polymers, referred to as “DuoMIPs”. The ratio of HPLC capacity factors (<i>k</i>′) for the analyte on each of the DuoMIPs is defined as the γ factor and can be used to determine AC when above 1.2. A mnemonic based on the complementary binding geometry of the DuoMIPs was used to aid in understanding and prediction of AC.