10.1021/ol500173y.s001
Danielle
S. Meador
Danielle
S.
Meador
David A. Spivak
David A.
Spivak
Absolute Configuration Determination Using Enantiomeric
Pairs of Molecularly Imprinted Polymers
American Chemical Society
2014
HPLC capacity factors
DuoMIP
Absolute Configuration Determination
binding geometry
AC
Molecularly Imprinted PolymersA
Enantiomeric Pairs
enantiomeric pair
γ factor
2014-03-07 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Absolute_Configuration_Determination_Using_Enantiomeric_Pairs_of_Molecularly_Imprinted_Polymers/2317069
A new method for
determination of absolute configuration (AC) is
demonstrated using an enantiomeric pair of molecularly imprinted polymers,
referred to as “DuoMIPs”. The ratio of HPLC capacity
factors (<i>k</i>′) for the analyte on each of the
DuoMIPs is defined as the γ factor and can be used to determine
AC when above 1.2. A mnemonic based on the complementary binding geometry
of the DuoMIPs was used to aid in understanding and prediction of
AC.