10.1021/ol500444z.s001 Andreu Vidal-Albalat Andreu Vidal-Albalat Santiago Rodríguez Santiago Rodríguez Florenci V. González Florenci V. González Nitroepoxides as Versatile Precursors to 1,4-Diamino Heterocycles American Chemical Society 2014 diamino diamine Versatile Precursors agent ammonia quinoxaline heterocycle Nitroepoxide access transformation HeterocyclesNitroepoxide tetrahydroquinoxaline bioactive structures benzenediamine piperazine pyrazine Diamino 2014-03-21 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Nitroepoxides_as_Versatile_Precursors_to_1_4_Diamino_Heterocycles/2313139 Nitroepoxides are easily transformed into 1,4-diamino heterocycles such as quinoxalines and pyrazines by treatment with 1,2-benzenediamines and ammonia, respectively. Additionally, related saturated heterocycles, such as piperazines and tetrahydroquinoxalines, can be accessed by treatment with 1,2-diamines and a reducing agent. These transformations are efficient, provide access privileged, bioactive structures, and produce minimal waste.