10.1021/ol500444z.s001
Andreu Vidal-Albalat
Andreu
Vidal-Albalat
Santiago Rodríguez
Santiago
Rodríguez
Florenci V. González
Florenci V.
González
Nitroepoxides as Versatile Precursors to 1,4-Diamino
Heterocycles
American Chemical Society
2014
diamino
diamine
Versatile Precursors
agent
ammonia
quinoxaline
heterocycle
Nitroepoxide
access
transformation
HeterocyclesNitroepoxide
tetrahydroquinoxaline
bioactive structures
benzenediamine
piperazine
pyrazine
Diamino
2014-03-21 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Nitroepoxides_as_Versatile_Precursors_to_1_4_Diamino_Heterocycles/2313139
Nitroepoxides
are easily transformed into 1,4-diamino heterocycles
such as quinoxalines and pyrazines by treatment with 1,2-benzenediamines
and ammonia, respectively. Additionally, related saturated heterocycles,
such as piperazines and tetrahydroquinoxalines, can be accessed by
treatment with 1,2-diamines and a reducing agent. These transformations
are efficient, provide access privileged, bioactive structures, and
produce minimal waste.