Capabilities of Single Particle Inductively Coupled
Plasma Mass Spectrometry for the Size Measurement of Nanoparticles:
A Case Study on Gold Nanoparticles
Jingyu Liu
Karen E. Murphy
Robert I. MacCuspie
Michael R. Winchester
10.1021/ac403775a.s001
https://acs.figshare.com/articles/journal_contribution/Capabilities_of_Single_Particle_Inductively_Coupled_Plasma_Mass_Spectrometry_for_the_Size_Measurement_of_Nanoparticles_A_Case_Study_on_Gold_Nanoparticles/2310634
The increasing application
of engineered nanomaterials (ENMs) in
consumer and medical products has motivated the development of single-particle
inductively coupled plasma mass spectrometry (spICP-MS) for characterizing
nanoparticles under realistic environmental exposure conditions. Recent
studies have established a set of metrological criteria and evaluated
the feasibility of spICP-MS for sizing or quantifying various highly
commercialized ENMs. However, less is known about the performance
of spICP-MS for detecting nanoparticles with sizes greater than 80
nm. This paper presents a systematic study on spICP-MS for accurate
size measurement of gold nanoparticles from 10 to 200 nm. We show
that dwell time contributes significantly to the quality of data,
with the optimal dwell time that limits split particle events, particle
coincidences and false positives being 10 ms. A simple approach to
correct for split particle events is demonstrated. We show that transient
features of single particle events can be temporally resolved on a
conventional quadrupole ICP-MS system using a sufficiently short dwell
time (0.1 ms). We propose an intensity-size diagram for estimating
the linear dynamic size range and guiding the selection of ICP-MS
operating conditions. The linear dynamic size range of the ICP-MS
system under standard (highest) sensitivity conditions is 10 to 70
nm but can be further extended to 200 nm by operating in less sensitive
modes. Finally, the ability of spICP-MS to characterize heterogeneous
forms of metal containing nanoparticles is evaluated in mixtures containing
both dissolved and poly disperse nanoparticulate Au.
2014-04-01 00:00:00
nanoparticle
ENM
limits split particle events
plasma mass spectrometry
split particle events
size range
200 nm
Plasma Mass Spectrometry
Single Particle Inductively