Domino Asymmetric Conjugate Addition–Conjugate Addition Nicolas Germain Doriane Schlaefli Mathieu Chellat Stéphane Rosset Alexandre Alexakis 10.1021/ol5005752.s001 https://acs.figshare.com/articles/journal_contribution/Domino_Asymmetric_Conjugate_Addition_Conjugate_Addition/2309242 Enantioenriched Al-, Mg-, and Zn-enolates undergo electrophilic trapping by nitroolefins and vinylsulfones to afford 1,4-diketones and 2-(bis­(phenyl­sulfonyl)­ethyl)­ketones in good yield and excellent diastereoselectivity. A one-pot preparation of indenes and enantiopure syntheses of tetra­hydro­benzo­furans, tetra­hydro­benzo­pyrroles, and azulenes are disclosed. A site-selective two-step sequence of three conjugate additions is also demonstrated. 2014-04-04 00:00:00 sequence enantiopure syntheses domino diastereoselectivity Asymmetric electrophilic azulene diketone Mg bi tetra AdditionEnantioenriched vinylsulfone Al conjugate additions preparation indene Conjugate nitroolefin