10.1021/am4059217.s001
Abhishek Bang
Abhishek
Bang
Anand
G. Sadekar
Anand
G.
Sadekar
Clayton Buback
Clayton
Buback
Brice Curtin
Brice
Curtin
Selin Acar
Selin
Acar
Damir Kolasinac
Damir
Kolasinac
Wei Yin
Wei
Yin
David A. Rubenstein
David A.
Rubenstein
Hongbing Lu
Hongbing
Lu
Nicholas Leventis
Nicholas
Leventis
Chariklia Sotiriou-Leventis
Chariklia
Sotiriou-Leventis
Evaluation
of Dysprosia Aerogels as Drug Delivery
Systems: A Comparative Study with Random and Ordered Mesoporous Silicas
American Chemical Society
2014
7 nm tubes
Drug release data
Mesoporous SilicasBiocompatible dysprosia aerogels
Drug Delivery Systems
drug uptake
dysprosia aerogels
drug release rate
2014-04-09 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Evaluation_of_Dysprosia_Aerogels_as_Drug_Delivery_Systems_A_Comparative_Study_with_Random_and_Ordered_Mesoporous_Silicas/2306911
Biocompatible dysprosia aerogels
were synthesized from DyCl<sub>3</sub>·6H<sub>2</sub>O and were
reinforced mechanically with
a conformal nano-thin-polyurea coating applied over their skeletal
framework. The random mesoporous space of dysprosia aerogels was filled
up to about 30% v/v with paracetamol, indomethacin, or insulin, and
the drug release rate was monitored spectrophotometrically in phosphate
buffer (pH = 7.4) or 0.1 M aqueous HCl. The drug uptake and release
study was conducted comparatively with polyurea-crosslinked random
silica aerogels, as well as with as-prepared (native) and polyurea-crosslinked
mesoporous silica perforated with ordered 7 nm tubes in hexagonal
packing. Drug uptake from random nanostructures (silica or dysprosia)
was higher (30–35% w/w) and the release rate was slower (typically
>20 h) relative to ordered silica (19–21% w/w, <1.5 h,
respectively).
Drug release data from dysprosia aerogels were fitted with a flux
equation consisting of three additive terms that correspond to drug
stored successively in three hierarchical pore sites on the skeletal
framework. The high drug uptake and slow release from dysprosia aerogels,
in combination with their low toxicity, strong paramagnetism, and
the possibility for neutron activation render those materials attractive
multifunctional vehicles for site-specific drug delivery.