Synthesis of α,β-Unsaturated Aldehydes
Based on a One-Pot Phase-Switch Dehydrogenative Cross-Coupling of
Primary Alcohols
Manuel
G. Mura
Lidia De Luca
Maurizio Taddei
Jonathan M. J. Williams
Andrea Porcheddu
10.1021/ol500916g.s001
https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Unsaturated_Aldehydes_Based_on_a_One_Pot_Phase_Switch_Dehydrogenative_Cross_Coupling_of_Primary_Alcohols/2292085
An
efficient <i>one-pot</i> ruthenium-catalyzed hydrogen-transfer
strategy for a direct access to α,β-unsaturated aldehydes
has been developed. The employment of enolates prepared in situ from
alcohols avoided handling unstable aldehydes and provided a very appealing
route to different cinnamaldehydes substituted in position 2. A silica-grafted
amine was used as phase-switch tag leading to a selective one-pot
process in favor of cross-dehydrogenative coupling products.
2014-05-16 00:00:00
tag
amine
Aldehyde
employment
enolate
position 2.
strategy
access
favor
aldehyde
Synthesi
Primary AlcoholsAn
handling
Dehydrogenative
cinnamaldehyde
Unsaturated