Synthesis of α,β-Unsaturated Aldehydes Based on a One-Pot Phase-Switch Dehydrogenative Cross-Coupling of Primary Alcohols Manuel G. Mura Lidia De Luca Maurizio Taddei Jonathan M. J. Williams Andrea Porcheddu 10.1021/ol500916g.s001 https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Unsaturated_Aldehydes_Based_on_a_One_Pot_Phase_Switch_Dehydrogenative_Cross_Coupling_of_Primary_Alcohols/2292085 An efficient <i>one-pot</i> ruthenium-catalyzed hydrogen-transfer strategy for a direct access to α,β-unsaturated aldehydes has been developed. The employment of enolates prepared in situ from alcohols avoided handling unstable aldehydes and provided a very appealing route to different cinnamaldehydes substituted in position 2. A silica-grafted amine was used as phase-switch tag leading to a selective one-pot process in favor of cross-dehydrogenative coupling products. 2014-05-16 00:00:00 tag amine Aldehyde employment enolate position 2. strategy access favor aldehyde Synthesi Primary AlcoholsAn handling Dehydrogenative cinnamaldehyde Unsaturated