10.1021/jo500145w.s001
Tian-Ze Li
Tian-Ze
Li
Xi-Bo Wang
Xi-Bo
Wang
Feng Sha
Feng
Sha
Xin-Yan Wu
Xin-Yan
Wu
Organocatalyzed Enantioselective
Mannich Reaction
of Pyrazoleamides with Isatin-Derived Ketimines
American Chemical Society
2014
ketimine
organocatalytic enantioselective Mannich reaction
diastereo
ee
Organocatalyzed Enantioselective Mannich Reaction
KetiminesThe
Pyrazoleamide
enantioselectivitie
pyrazoleamide
dr
chiral
amide
yield
2014-05-16 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Organocatalyzed_Enantioselective_Mannich_Reaction_of_Pyrazoleamides_with_Isatin_Derived_Ketimines/2290999
The first organocatalytic enantioselective
Mannich reaction of
pyrazoleamides with isatin-derived <i>N</i>-Boc ketimines
has been developed to afford 2-oxindole-based chiral β-amino
amides in good yields (84–97%) with excellent diastereo- and
enantioselectivities (up to 99:1 dr and >99% ee).