10.1021/jo500145w.s002 Tian-Ze Li Tian-Ze Li Xi-Bo Wang Xi-Bo Wang Feng Sha Feng Sha Xin-Yan Wu Xin-Yan Wu Organocatalyzed Enantioselective Mannich Reaction of Pyrazoleamides with Isatin-Derived Ketimines American Chemical Society 2014 ketimine organocatalytic enantioselective Mannich reaction diastereo ee Organocatalyzed Enantioselective Mannich Reaction KetiminesThe Pyrazoleamide enantioselectivitie pyrazoleamide dr chiral amide yield 2014-05-16 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Organocatalyzed_Enantioselective_Mannich_Reaction_of_Pyrazoleamides_with_Isatin_Derived_Ketimines/2290996 The first organocatalytic enantioselective Mannich reaction of pyrazoleamides with isatin-derived <i>N</i>-Boc ketimines has been developed to afford 2-oxindole-based chiral β-amino amides in good yields (84–97%) with excellent diastereo- and enantioselectivities (up to 99:1 dr and >99% ee).