Lago-Santomé, Hugo Meana-Pañeda, Rubén Alonso, Ricardo A Convergent Approach to the Dioxaadamantane Core of (±)-Tetrodotoxin A fully stereocontrolled 1,3-diol orthoesterification and a water-promoted intramolecular Henry addition, combined with the previously reported formal (3 + 3) annulation of α-nitro-α,β-enals and 2,2-dimethyl-1,3-dioxan-5-one, provided for a short convergent pathway to the dioxaadamantane core of (±)-tetrodotoxin. intramolecular;convergent pathway;Convergent Approach;TetrodotoxinA;annulation;dimethyl;dioxaadamantane core;orthoesterification;nitro;diol;stereocontrolled;Henry;tetrodotoxin;Dioxaadamantane Core 2014-05-16
    https://acs.figshare.com/articles/journal_contribution/A_Convergent_Approach_to_the_Dioxaadamantane_Core_of_Tetrodotoxin/2290987
10.1021/jo500056w.s001