Metallo-Folded Single-Chain Nanoparticles with Catalytic
Selectivity
Ana Sanchez-Sanchez
Arantxa Arbe
Juan Colmenero
José A. Pomposo
10.1021/mz5001477.s001
https://acs.figshare.com/articles/journal_contribution/Metallo_Folded_Single_Chain_Nanoparticles_with_Catalytic_Selectivity/2290489
Mimicking the substrate specificity
and catalytic activity of enzymes
is of great interest for different fields (e.g., chemistry, biology,
nanomedicine). Enhanced reaction rates using artificial, enzyme-mimic
catalysts based on a variety of molecular structures and nanoentities
(e.g., macrocyclic compounds, star and helical polymers, dendrimers)
have been previously reported. However, examples of enzyme-sized soft
entities displaying substrate specificity are certainly scarce. Herein,
we report the synthesis and characterization of single-chain nanoparticles
based on metallo-folded polymer chains containing complexed Cu(II)
ions showing catalytic specificity during the oxidative coupling of
mixtures of chemically related terminal acetylene substrates. This
work paves the way for the easy and efficient construction of other
Pd-, Ni-, Co-, Fe-, Mn-, or Mo-containing soft nanoentities approaching
the substrate specificity of natural enzymes for a variety of organic
reactions.
2014-05-20 00:00:00
polymer
nanoentitie
variety
Enhanced reaction rates
substrate specificity
enzyme
e.g
terminal acetylene substrates