10.1021/jf500387d.s003
Ting Wang
Ting
Wang
Peng Sun
Peng
Sun
Liang Chen
Liang
Chen
Qi Huang
Qi
Huang
Kaixian Chen
Kaixian
Chen
Qi Jia
Qi
Jia
Yiming Li
Yiming
Li
Heyao Wang
Heyao
Wang
Cinnamtannin
D‑1 Protects Pancreatic β‑Cells
from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress
American Chemical Society
2014
procyanidin
MIN 6 cells
islet
antidiabetic
oligomer
mechanism
Attenuating Oxidative StressIn
oxidative stress
tamala
palmitic
CD 1
pancreatic
INS
H 2O apoptosis
2014-06-04 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Cinnamtannin_D_1_Protects_Pancreatic_Cells_from_Palmitic_Acid_Induced_Apoptosis_by_Attenuating_Oxidative_Stress/2286862
In previous studies, A-type procyanidin oligomers isolated from Cinnamomum tamala were proved to possess antidiabetic
effect and protect pancreatic β-cells in vivo. The aim of this
study was to unveil the mechanisms of protecting pancreatic β-cells
from palmitic acid-induced apoptosis by cinnamtannin D-1 (CD1), one
of the main A-type procyanidin oligomers in <i>C. tamala</i>. CD1 was discovered to dose-dependently reduce palmitic acid- or
H<sub>2</sub>O<sub>2</sub>-induced apoptosis and oxidative stress
in INS-1 cells, MIN6 cells, and primary cultured murine islets. Moreover,
CD1 could reverse palmitic acid-induced dysfunction of glucose-stimulated
insulin secretion in primary cultured islets. These results indicate
that reduction of apoptosis and oxidative stress might account for
the protection effect of CD1, which provided a better understanding
of the mechanisms of the antidiabetic effects of procyanidin oligomers.