Efficient Functionalization of Oligonucleotides by
New Achiral Nonnucleosidic Monomers
Maxim
S. Kupryushkin
Mikhail D. Nekrasov
Dmitry A. Stetsenko
Dmitrii V. Pyshnyi
10.1021/ol500668n.s002
https://acs.figshare.com/articles/journal_contribution/Efficient_Functionalization_of_Oligonucleotides_by_New_Achiral_Nonnucleosidic_Monomers/2285476
A novel
synthetic strategy has been designed for preparation of achiral nonnucleosidic
phosphoramidite monomers for automated solid-phase oligonucleotide
synthesis. It is based on <i>O</i>-DMTr-protected 4-(2-hydroxyethyl)-morpholine-2,3-dione
as the key compound and a family of building blocks obtained by its
ring-opening by primary aliphatic amines. A series of nonnucleosidic
phosphoramidites containing various side-chain functionalities was
synthesized, and corresponding oligodeoxyribonucleotides incorporating
modified units in single or multiple positions along the chain were
prepared.
2014-06-06 00:00:00
building blocks
series
New Achiral Nonnucleosidic MonomersA novel
hydroxyethyl
aliphatic amines
strategy
Oligonucleotide
synthesis
functionalitie
nonnucleosidic phosphoramidites
oligonucleotide
compound
achiral nonnucleosidic phosphoramidite monomers
Efficient Functionalization
preparation
oligodeoxyribonucleotide