10.1021/jo5005839.s003 Hua Cai Hua Cai Jing Nie Jing Nie Yan Zheng Yan Zheng Jun-An Ma Jun-An Ma Lithium Binaphtholate-Catalyzed Enantioselective Enyne Addition to Ketones: Access to Enynylated Tertiary Alcohols American Chemical Society 2014 bicyclic product addition reaction Efavirenz analogue chiral lithium binaphtholate Convenient transformation enyne addition Enynylated Tertiary AlcoholsA enantioselective enyne addition 2014-06-20 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Lithium_Binaphtholate_Catalyzed_Enantioselective_Enyne_Addition_to_Ketones_Access_to_Enynylated_Tertiary_Alcohols/2280892 A new catalytic enantioselective enyne addition to ketones has been developed. In the presence of chiral lithium binaphtholate, the addition reaction proceeded smoothly to produce a series of enynylated tertiary alcohols in up to 96% yield and 94% enantiomeric excess. Convenient transformation of the adduct via Pauson–Khand cycloaddition reaction afforded the bicyclic product without detectable loss of enantioselectivity. Furthermore, catalytic asymmetric enyne addition to trifluoromethylketone was applied in the synthesis of the Efavirenz analogue.