Mild Fluorination of Chloropyridines with in Situ Generated Anhydrous Tetrabutylammonium Fluoride AllenLaura J. MuhuhiJoseck M. BlandDouglas C. MerzelRachel SanfordMelanie S. 2014 This paper describes the fluorination of nitrogen heterocycles using anhydrous NBu<sub>4</sub>F. Quinoline derivatives as well as a number of 3- and 5-substituted pyridines undergo high-yielding fluorination at room temperature using this reagent. These results with anhydrous NBu<sub>4</sub>F compare favorably to traditional halex fluorinations using alkali metal fluorides, which generally require temperatures of ≥100 °C.