10.1021/ol501389k.s001
Olivier René
Olivier
René
Benjamin P. Fauber
Benjamin P.
Fauber
Sushant Malhotra
Sushant
Malhotra
Herbert Yajima
Herbert
Yajima
Palladium-Catalyzed α‑Arylation of Sultams
with Aryl and Heteroaryl Iodides
American Chemical Society
2014
diastereomeric ratios
arylation
Arylation
Heteroaryl
Sultam
propanesultam
cis product
Aryl
heteroaryl iodides
sultam
yield
IodidesPalladium
2014-07-03 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Palladium_Catalyzed_Arylation_of_Sultams_with_Aryl_and_Heteroaryl_Iodides/2277868
Palladium(0)-catalyzed conditions
for the α-arylation of
sultams with aryl and heteroaryl iodides have been developed. Arylation
of 3-substituted 1,3-propanesultams gave rise to high yields and high
diastereomeric ratios, leading to the thermodynamically favored <i>cis</i> product. The arylation was broadly applicable to various
electron-rich and electron-poor (hetero)aromatic iodides.