Controlling
the Exothermicity of <i>O</i>‑Arylation by Evaporative
Cooling during the Process Development
of Fluoxetine Hydrochloride
Sandeep Mohanty
Amrendra
Kumar Roy
S. Phani Kiran
G. Eduardo Rafael
K. P.
Vinay Kumar
A. Chandra Karmakar
10.1021/op400279n.s002
https://acs.figshare.com/articles/journal_contribution/Controlling_the_Exothermicity_of_i_O_i_Arylation_by_Evaporative_Cooling_during_the_Process_Development_of_Fluoxetine_Hydrochloride/2273368
This
study illustrates the optimization of the <i>O</i>-arylation
step of fluoxetine hydrochloride (<b>1</b>) synthesis.
In the entire process, this is the most critical step that dictates
the yield and quality of the product. The highlight of the process
is the concept of evaporative cooling that was employed in manipulating
the above highly exothermic reaction by introducing toluene as the
cosolvent. The evaporative cooling not only aided in getting an efficient
procedure but also increased the yield of <b>1</b> and simplified
the work-up procedure. This was a protective approach adopted for
process safety, considering the worst-case scenario in the plant.
2014-07-18 00:00:00
Process Development
cooling
Fluoxetine HydrochlorideThis study
process safety
Evaporative Cooling
procedure