%0 Journal Article %A White, James D. %A Shaw, Subrata %D 2014 %T A New Cobalt–Salen Catalyst for Asymmetric Cyclopropanation. Synthesis of the Serotonin–Norepinephrine Repuptake Inhibitor (+)-Synosutine %U https://acs.figshare.com/articles/journal_contribution/A_New_Cobalt_Salen_Catalyst_for_Asymmetric_Cyclopropanation_Synthesis_of_the_Serotonin_Norepinephrine_Repuptake_Inhibitor_Synosutine/2269234 %R 10.1021/ol501549x.s001 %2 https://acs.figshare.com/ndownloader/files/3905254 %K ci %K ethyl diazoacetate %K presence %K cobalt %K disubstituted %K New %K SynosutineA %K Asymmetric cyclopropanation %K Repuptake %K ethylene %K chiral scaffold %K diastereo %K Serotonin %K enantioselectivity %K Catalyst %K potassium thioacetate %K inhibitor %K C 2 %K Synthesi %K reuptake %K cyclopropane %K formation %K catalyst %K Inhibitor %K serotonin %K Asymmetric Cyclopropanation %K promoter %K Cobalt %K synosutine %K synthesis %X A new C2 symmetric cobalt­(II)–salen catalyst based on cis-2,5-diamino­bicyclo­[2.2.2]­octane as the chiral scaffold was prepared which, in the presence of potassium thioacetate as the promoter, catalyzed the formation of cyclopropanes from 1,1-disubstituted ethylenes and ethyl diazoacetate in high yield and with excellent diastereo- and enantioselectivity. Asymmetric cyclopropanation with the catalyst was used in a short, efficient synthesis of the dual serotonin–epinephrine reuptake inhibitor (+)-synosutine. %I ACS Publications