%0 Journal Article
%A White, James D.
%A Shaw, Subrata
%D 2014
%T A New Cobalt–Salen Catalyst for Asymmetric
Cyclopropanation. Synthesis of the Serotonin–Norepinephrine
Repuptake Inhibitor (+)-Synosutine
%U https://acs.figshare.com/articles/journal_contribution/A_New_Cobalt_Salen_Catalyst_for_Asymmetric_Cyclopropanation_Synthesis_of_the_Serotonin_Norepinephrine_Repuptake_Inhibitor_Synosutine/2269234
%R 10.1021/ol501549x.s001
%2 https://acs.figshare.com/ndownloader/files/3905254
%K ci
%K ethyl diazoacetate
%K presence
%K cobalt
%K disubstituted
%K New
%K SynosutineA
%K Asymmetric cyclopropanation
%K Repuptake
%K ethylene
%K chiral scaffold
%K diastereo
%K Serotonin
%K enantioselectivity
%K Catalyst
%K potassium thioacetate
%K inhibitor
%K C 2
%K Synthesi
%K reuptake
%K cyclopropane
%K formation
%K catalyst
%K Inhibitor
%K serotonin
%K Asymmetric Cyclopropanation
%K promoter
%K Cobalt
%K synosutine
%K synthesis
%X A new C2 symmetric cobalt(II)–salen
catalyst based on cis-2,5-diaminobicyclo[2.2.2]octane
as the chiral scaffold was prepared which, in the presence of potassium
thioacetate as the promoter, catalyzed the formation of cyclopropanes
from 1,1-disubstituted ethylenes and ethyl diazoacetate in high yield
and with excellent diastereo- and enantioselectivity. Asymmetric cyclopropanation
with the catalyst was used in a short, efficient synthesis of the
dual serotonin–epinephrine reuptake inhibitor (+)-synosutine.
%I ACS Publications