10.1021/ol501549x.s001 James D. White James D. White Subrata Shaw Subrata Shaw A New Cobalt–Salen Catalyst for Asymmetric Cyclopropanation. Synthesis of the Serotonin–Norepinephrine Repuptake Inhibitor (+)-Synosutine American Chemical Society 2014 ci ethyl diazoacetate presence cobalt disubstituted New SynosutineA Asymmetric cyclopropanation Repuptake ethylene chiral scaffold diastereo Serotonin enantioselectivity Catalyst potassium thioacetate inhibitor C 2 Synthesi reuptake cyclopropane formation catalyst Inhibitor serotonin Asymmetric Cyclopropanation promoter Cobalt synosutine synthesis 2014-08-01 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/A_New_Cobalt_Salen_Catalyst_for_Asymmetric_Cyclopropanation_Synthesis_of_the_Serotonin_Norepinephrine_Repuptake_Inhibitor_Synosutine/2269234 A new <i>C</i><sub>2</sub> symmetric cobalt­(II)–salen catalyst based on <i>cis</i>-2,5-diamino­bicyclo­[2.2.2]­octane as the chiral scaffold was prepared which, in the presence of potassium thioacetate as the promoter, catalyzed the formation of cyclopropanes from 1,1-disubstituted ethylenes and ethyl diazoacetate in high yield and with excellent diastereo- and enantioselectivity. Asymmetric cyclopropanation with the catalyst was used in a short, efficient synthesis of the dual serotonin–epinephrine reuptake inhibitor (+)-synosutine.