Messori, Luigi Marzo, Tiziano Michelucci, Elena Krauss, Irene Russo Navarro-Ranninger, Carmen Quiroga, Adoracion G. Merlino, Antonello Interactions between Anticancer <i>trans</i>-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of <i>trans</i>-(Dimethylamino)(methylamino)dichloridoplatinum(II) The adducts formed between <i>trans</i>-(dimethylamino)­(methylamino)­dichloridoplatinum­(II), [t-PtCl<sub>2</sub>(dma)­(ma)], and two model proteins, i.e., hen egg white lysozyme and bovine pancreatic ribonuclease, were independently characterized by X-ray crystallography and electrospray ionization mass spectrometry. In these adducts, the Pt<sup>II</sup> center, upon chloride release, coordinates either to histidine or aspartic acid residues while both alkylamino ligands remain bound to the metal. Comparison with the cisplatin derivatives of the same proteins highlights for [t-PtCl<sub>2</sub>(dma)­(ma)] a kind of biomolecular metalation remarkably different from that of cisplatin. adduct;coordinate;cisplatin derivatives;biomolecular metalation;chloride release;crystallography;kind;Crystal Structures;pancreatic ribonuclease;Compound;Interaction;Spectra;Proteins;PtII center;aspartic acid residues;histidine;i.e;Anticancer;Protein Adducts;alkylamino ligands;lysozyme;tran;electrospray ionization mass spectrometry;model proteins 2014-08-04
    https://acs.figshare.com/articles/journal_contribution/Interactions_between_Anticancer_i_trans_i_Platinum_Compounds_and_Proteins_Crystal_Structures_and_ESI_MS_Spectra_of_Two_Protein_Adducts_of_i_trans_i_Dimethylamino_methylamino_dichloridoplatinum_II_/2268775
10.1021/ic5012583.s001