%0 Journal Article %A Messori, Luigi %A Marzo, Tiziano %A Michelucci, Elena %A Krauss, Irene Russo %A Navarro-Ranninger, Carmen %A Quiroga, Adoracion G. %A Merlino, Antonello %D 2014 %T Interactions between Anticancer trans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino)(methylamino)dichloridoplatinum(II) %U https://acs.figshare.com/articles/journal_contribution/Interactions_between_Anticancer_i_trans_i_Platinum_Compounds_and_Proteins_Crystal_Structures_and_ESI_MS_Spectra_of_Two_Protein_Adducts_of_i_trans_i_Dimethylamino_methylamino_dichloridoplatinum_II_/2268775 %R 10.1021/ic5012583.s001 %2 https://acs.figshare.com/ndownloader/files/3904789 %K adduct %K coordinate %K cisplatin derivatives %K biomolecular metalation %K chloride release %K crystallography %K kind %K Crystal Structures %K pancreatic ribonuclease %K Compound %K Interaction %K Spectra %K Proteins %K PtII center %K aspartic acid residues %K histidine %K i.e %K Anticancer %K Protein Adducts %K alkylamino ligands %K lysozyme %K tran %K electrospray ionization mass spectrometry %K model proteins %X The adducts formed between trans-(dimethylamino)­(methylamino)­dichloridoplatinum­(II), [t-PtCl2(dma)­(ma)], and two model proteins, i.e., hen egg white lysozyme and bovine pancreatic ribonuclease, were independently characterized by X-ray crystallography and electrospray ionization mass spectrometry. In these adducts, the PtII center, upon chloride release, coordinates either to histidine or aspartic acid residues while both alkylamino ligands remain bound to the metal. Comparison with the cisplatin derivatives of the same proteins highlights for [t-PtCl2(dma)­(ma)] a kind of biomolecular metalation remarkably different from that of cisplatin. %I ACS Publications