Interactions between Anticancer <i>trans</i>-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of <i>trans</i>-(Dimethylamino)(methylamino)dichloridoplatinum(II) Luigi Messori Tiziano Marzo Elena Michelucci Irene Russo Krauss Carmen Navarro-Ranninger Adoracion G. Quiroga Antonello Merlino 10.1021/ic5012583.s001 https://acs.figshare.com/articles/journal_contribution/Interactions_between_Anticancer_i_trans_i_Platinum_Compounds_and_Proteins_Crystal_Structures_and_ESI_MS_Spectra_of_Two_Protein_Adducts_of_i_trans_i_Dimethylamino_methylamino_dichloridoplatinum_II_/2268775 The adducts formed between <i>trans</i>-(dimethylamino)­(methylamino)­dichloridoplatinum­(II), [t-PtCl<sub>2</sub>(dma)­(ma)], and two model proteins, i.e., hen egg white lysozyme and bovine pancreatic ribonuclease, were independently characterized by X-ray crystallography and electrospray ionization mass spectrometry. In these adducts, the Pt<sup>II</sup> center, upon chloride release, coordinates either to histidine or aspartic acid residues while both alkylamino ligands remain bound to the metal. Comparison with the cisplatin derivatives of the same proteins highlights for [t-PtCl<sub>2</sub>(dma)­(ma)] a kind of biomolecular metalation remarkably different from that of cisplatin. 2014-08-04 00:00:00 adduct coordinate cisplatin derivatives biomolecular metalation chloride release crystallography kind Crystal Structures pancreatic ribonuclease Compound Interaction Spectra Proteins PtII center aspartic acid residues histidine i.e Anticancer Protein Adducts alkylamino ligands lysozyme tran electrospray ionization mass spectrometry model proteins