Interactions
between Anticancer <i>trans</i>-Platinum Compounds and Proteins:
Crystal Structures and ESI-MS Spectra
of Two Protein Adducts of <i>trans</i>-(Dimethylamino)(methylamino)dichloridoplatinum(II)
Luigi Messori
Tiziano Marzo
Elena Michelucci
Irene Russo Krauss
Carmen Navarro-Ranninger
Adoracion G. Quiroga
Antonello Merlino
10.1021/ic5012583.s001
https://acs.figshare.com/articles/journal_contribution/Interactions_between_Anticancer_i_trans_i_Platinum_Compounds_and_Proteins_Crystal_Structures_and_ESI_MS_Spectra_of_Two_Protein_Adducts_of_i_trans_i_Dimethylamino_methylamino_dichloridoplatinum_II_/2268775
The adducts formed between <i>trans</i>-(dimethylamino)(methylamino)dichloridoplatinum(II),
[t-PtCl<sub>2</sub>(dma)(ma)], and two model proteins, i.e., hen egg
white lysozyme and bovine pancreatic ribonuclease, were independently
characterized by X-ray crystallography and electrospray ionization
mass spectrometry. In these adducts, the Pt<sup>II</sup> center, upon
chloride release, coordinates either to histidine or aspartic acid
residues while both alkylamino ligands remain bound to the metal.
Comparison with the cisplatin derivatives of the same proteins highlights
for [t-PtCl<sub>2</sub>(dma)(ma)] a kind of biomolecular metalation
remarkably different from that of cisplatin.
2014-08-04 00:00:00
adduct
coordinate
cisplatin derivatives
biomolecular metalation
chloride release
crystallography
kind
Crystal Structures
pancreatic ribonuclease
Compound
Interaction
Spectra
Proteins
PtII center
aspartic acid residues
histidine
i.e
Anticancer
Protein Adducts
alkylamino ligands
lysozyme
tran
electrospray ionization mass spectrometry
model proteins