10.1021/ac501586d.s002 Andrew Kucher Andrew Kucher Lauren M. Jackson Lauren M. Jackson Jordan O. Lerach Jordan O. Lerach A. N. Bloom A. N. Bloom N. J. Popczun N. J. Popczun Andreas Wucher Andreas Wucher Nicholas Winograd Nicholas Winograd Near Infrared (NIR) Strong Field Ionization and Imaging of C<sub>60</sub> Sputtered Molecules: Overcoming Matrix Effects and Improving Sensitivity American Chemical Society 2014 rubrene SFI SNMS mouse brain sections SIMS molecule C 60 Sputtered Molecules Botryococcus braunii algal cell colonies SensitivityStrong field ionization Overcoming Matrix Effects Strong Field Ionization NIR signal 2014-09-02 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Near_Infrared_NIR_Strong_Field_Ionization_and_Imaging_of_C_sub_60_sub_Sputtered_Molecules_Overcoming_Matrix_Effects_and_Improving_Sensitivity/2258923 Strong field ionization (SFI) was applied for the secondary neutral mass spectrometry (SNMS) of patterned rubrene films, mouse brain sections, and Botryococcus braunii algal cell colonies. Molecular ions of rubrene, cholesterol, C<sub>31</sub> diene/triene, and three wax monoesters were detected, representing some of the largest organic molecules ever ionized intact by a laser post-ionization experiment. In rubrene, the SFI SNMS molecular ion signal was ∼4 times higher than in the corresponding secondary-ion mass spectroscopy (SIMS) analysis. In the biological samples, the achieved signal improvements varied among molecules and sampling locations, with SFI SNMS, in some cases, revealing analytes made completely undetectable by the influence of matrix effects in SIMS.