Sadhu, Pradeep Alla, Santhosh Kumar Punniyamurthy, Tharmalingam Room-Temperature Cu(II)-Catalyzed Chemo- and Regioselective <i>Ortho</i>-Nitration of Arenes via C–H Functionalization An efficient Cu-catalyzed chemo- and regioselective <i>ortho</i>-nitration of <i>N</i>,1-diaryl-5-aminotetrazoles and <i>N</i>,4-diaryl-3-amino-1,2,4-triazoles has been described with good functional group compatibility. The procedure features the use of an operationally simple protocol utilizing the commercially available less toxic CuCl<sub>2</sub>·2H<sub>2</sub>O as catalyst and Fe­(NO<sub>3</sub>)<sub>3</sub>·9H<sub>2</sub>O as nitration source at room temperature. Removal of the 5-aminotetrazole directing group has been demonstrated using base hydrolysis to afford substituted 2-nitroanilines. nitration source;Regioselective;CuCl;aminotetrazole;removal;regioselective;procedure features;FunctionalizationAn;nitroaniline;Fe;Arene;catalyst;Chemo;group compatibility;room temperature;chemo;base hydrolysis;Cu 2014-09-19
    https://acs.figshare.com/articles/journal_contribution/Room_Temperature_Cu_II_Catalyzed_Chemo_and_Regioselective_i_Ortho_i_Nitration_of_Arenes_via_C_H_Functionalization/2253520
10.1021/jo501617g.s003