Enantioselective Catalytic Fluorinative Aza-semipinacol Rearrangement Romanov-MichailidisFedor PupierMarion BesnardCéline BürgiThomas AlexakisAlexandre 2014 An efficient and highly stereoselective fluorinative aza-semipinacol rearrangement is described. The catalytic reaction requires use of Selectfluor in combination with the chiral, enantiopure phosphate anion derived from acid <b>L3</b>. Under optimized conditions, cyclopropylamines <b>A</b> were transformed into β-fluoro cyclobutylimines <b>B</b> in good yields and high levels of diastereo- and enantiocontrol. Furthermore, the optically active cyclobutylimines were reduced diastereoselectively with L-Selectride in the corresponding fluorinated amines <b>C</b>, compounds of significant interest in the pharmacological industry.