%0 Generic
%A Yan, Bing-Chao
%A Wang, Wei-Guang
%A Hu, Dong-Bao
%A Sun, Xiang
%A Kong, Ling-Mei
%A Li, Xiao-Nian
%A Du, Xue
%A Luo, Shi-Hong
%A Liu, Yan
%A Li, Yan
%A Sun, Han-Dong
%A Pu, Jian-Xin
%D 2016
%T Phomopchalasins A and B, Two Cytochalasans with Polycyclic-Fused
Skeletons from the Endophytic Fungus Phomopsis sp.
shj2
%U https://acs.figshare.com/articles/dataset/Phomopchalasins_A_and_B_Two_Cytochalasans_with_Polycyclic_Fused_Skeletons_from_the_Endophytic_Fungus_i_Phomopsis_i_sp_shj2/2245117
%R 10.1021/acs.orglett.6b00214.s004
%2 https://acs.figshare.com/ndownloader/files/3881071
%K novel cytochalasans
%K calculation
%K carbon skeletons
%K antimigratory activities
%K Endophytic Fungus Phomopsis sp
%K tetracyclic ring system
%K ECD
%K Isodon eriocalyx var
%K dichroism
%K cytotoxic
%K laxiflora
%K phomopchalasin
%K spectroscopic analyses
%K Skeleton
%K endophytic fungus Phomopsis sp
%K shj 2Phomopchalasins
%K analysis
%K hydroperoxyl motif
%K pentacyclic skeleton
%K Cytochalasan
%X Phomopchalasins A (1) and B (2), two
novel cytochalasans with unprecedented carbon skeletons, and phomopchalasin
C (3), containing a rare hydroperoxyl motif, were obtained
from the endophytic fungus Phomopsis sp. shj2, which
was first isolated from the Isodon eriocalyx var. laxiflora. Their structures were elucidated by extensive spectroscopic analyses,
electronic circular dichroism (ECD) calculation, and X-ray crystallographic
analysis. Notably, 1 possessed an unprecedented 5/6/5/8-fused
tetracyclic ring system, and 2 featured a novel 5/6/6/7/5-fused
pentacyclic skeleton. The cytotoxic, anti-inflammatory, and antimigratory
activities of 1–3 were evaluated
in vitro.
%I ACS Publications