%0 Generic %A Yan, Bing-Chao %A Wang, Wei-Guang %A Hu, Dong-Bao %A Sun, Xiang %A Kong, Ling-Mei %A Li, Xiao-Nian %A Du, Xue %A Luo, Shi-Hong %A Liu, Yan %A Li, Yan %A Sun, Han-Dong %A Pu, Jian-Xin %D 2016 %T Phomopchalasins A and B, Two Cytochalasans with Polycyclic-Fused Skeletons from the Endophytic Fungus Phomopsis sp. shj2 %U https://acs.figshare.com/articles/dataset/Phomopchalasins_A_and_B_Two_Cytochalasans_with_Polycyclic_Fused_Skeletons_from_the_Endophytic_Fungus_i_Phomopsis_i_sp_shj2/2245117 %R 10.1021/acs.orglett.6b00214.s004 %2 https://acs.figshare.com/ndownloader/files/3881071 %K novel cytochalasans %K calculation %K carbon skeletons %K antimigratory activities %K Endophytic Fungus Phomopsis sp %K tetracyclic ring system %K ECD %K Isodon eriocalyx var %K dichroism %K cytotoxic %K laxiflora %K phomopchalasin %K spectroscopic analyses %K Skeleton %K endophytic fungus Phomopsis sp %K shj 2Phomopchalasins %K analysis %K hydroperoxyl motif %K pentacyclic skeleton %K Cytochalasan %X Phomopchalasins A (1) and B (2), two novel cytochalasans with unprecedented carbon skeletons, and phomopchalasin C (3), containing a rare hydroperoxyl motif, were obtained from the endophytic fungus Phomopsis sp. shj2, which was first isolated from the Isodon eriocalyx var. laxiflora. Their structures were elucidated by extensive spectroscopic analyses, electronic circular dichroism (ECD) calculation, and X-ray crystallographic analysis. Notably, 1 possessed an unprecedented 5/6/5/8-fused tetracyclic ring system, and 2 featured a novel 5/6/6/7/5-fused pentacyclic skeleton. The cytotoxic, anti-inflammatory, and antimigratory activities of 13 were evaluated in vitro. %I ACS Publications