Zhao, Si-Meng Wang, Zhe Zeng, Guang-Zhi Song, Wei-Wu Chen, Xiao-Qiang Li, Xiao-Nian Tan, Ning-Hua New Cytotoxic Naphthohydroquinone Dimers from <i>Rubia alata</i> Two novel naphthohydroquinone dimers with unprecedented skeletons, rubialatins A (<b>1</b>) and B (<b>2</b>), were isolated from the herbal plant <i>Rubia alata</i> together with their precursor, mollugin (<b>3</b>). The structures were elucidated on the basis of NMR spectra and crystal X-ray diffraction. Compound <b>1</b>, a racemate, was separated by chiral column chromatography, and the absolute configurations of the enantiomers were determined by the computational methods. Cytotoxicity of <b>1</b>–<b>3</b> was evaluated as well as the effect on the NF-κB pathway. Compound (+)-<b>1</b> showed cytotoxicity and could inhibit NF-κB pathway. Meanwhile, <b>2</b> showed cytotoxicity and a synergistic effect with TNF-α on NF-κB activation. chiral column chromatography;Rubia alataTwo novel naphthohydroquinone dimers;plant Rubia alata;NF;Compound;New Cytotoxic Naphthohydroquinone Dimers;TNF;cytotoxicity;NMR spectra;pathway 2014-11-07
    https://acs.figshare.com/articles/dataset/New_Cytotoxic_Naphthohydroquinone_Dimers_from_i_Rubia_alata_i_/2237911
10.1021/ol502603f.s001