New Cytotoxic Naphthohydroquinone Dimers from <i>Rubia alata</i>
Si-Meng Zhao
Zhe Wang
Guang-Zhi Zeng
Wei-Wu Song
Xiao-Qiang Chen
Xiao-Nian Li
Ning-Hua Tan
10.1021/ol502603f.s001
https://acs.figshare.com/articles/dataset/New_Cytotoxic_Naphthohydroquinone_Dimers_from_i_Rubia_alata_i_/2237911
Two novel naphthohydroquinone dimers
with unprecedented skeletons,
rubialatins A (<b>1</b>) and B (<b>2</b>), were isolated
from the herbal plant <i>Rubia alata</i> together with their
precursor, mollugin (<b>3</b>). The structures were elucidated
on the basis of NMR spectra and crystal X-ray diffraction. Compound <b>1</b>, a racemate, was separated by chiral column chromatography,
and the absolute configurations of the enantiomers were determined
by the computational methods. Cytotoxicity of <b>1</b>–<b>3</b> was evaluated as well as the effect on the NF-κB pathway.
Compound (+)-<b>1</b> showed cytotoxicity and could inhibit
NF-κB pathway. Meanwhile, <b>2</b> showed cytotoxicity
and a synergistic effect with TNF-α on NF-κB activation.
2014-11-07 00:00:00
chiral column chromatography
Rubia alataTwo novel naphthohydroquinone dimers
plant Rubia alata
NF
Compound
New Cytotoxic Naphthohydroquinone Dimers
TNF
cytotoxicity
NMR spectra
pathway