Lorente, Adriana Albericio, Fernando Álvarez, Mercedes Selective Formation of a <i>Z</i>‑Trisubstituted Double Bond Using a 1‑(<i>tert</i>-Butyl)tetrazolyl Sulfone In our effort to gain further insight into the enantioselective synthesis of the structural core of phormidolides B and C, we have discovered the formation of a <i>Z</i>-trisubstituted double bond. Here, we describe a highly selective process that can be applied to our target following a strategy that is based on Julia–Kocienski olefination. The use of 1-(<i>tert</i>-butyl)­tetrazolyl sulfone affords the construction of the <i>Z</i>-trisubstituted alkene with high efficiency and stereoselectivity. SulfoneIn;insight;alkene;olefination;phormidolides B;strategy;sulfone;enantioselective synthesis;core;Selective Formation;construction;formation;gain;stereoselectivity;effort;Bond;efficiency;Julia;bond 2014-11-07
    https://acs.figshare.com/articles/journal_contribution/Selective_Formation_of_a_i_Z_i_Trisubstituted_Double_Bond_Using_a_1_i_tert_i_Butyl_tetrazolyl_Sulfone/2237758
10.1021/jo501988e.s001