10.1021/ol5034139.s001
Dandan Han
Dandan
Han
Zhiming Li
Zhiming
Li
Renhua Fan
Renhua
Fan
Oxidative Nucleophilic Cyclization of 2‑Alkynylanilines with Thiophenols under Metal-Free Conditions
American Chemical Society
2014
PhI
ConditionsAn
alkynylaniline
thiophenol
dearomatization
Br ønsted acid
nucleophilic cyclization
DFT calculations
oxidative
Oxidative Nucleophilic Cyclization
Alkynylaniline
Thiophenol
reaction pathway
2014-12-19 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Oxidative_Nucleophilic_Cyclization_of_2_Alkynylanilines_with_Thiophenols_under_Metal_Free_Conditions/2224024
An
oxidative nucleophilic cyclization of 2-alkynylanilines with
thiophenols under metal-free conditions was developed. The one-pot
two-step reaction involves a PhI(OAc)<sub>2</sub>-mediated oxidative
dearomatization and a Brønsted acid promoted nucleophilic cyclization.
DFT calculations were performed to understand the reaction pathway.