10.1021/ol503371r.s001 He Zhang He Zhang Yong-Ming Sun Yong-Ming Sun Yalei Zhao Yalei Zhao Zhong-Yang Zhou Zhong-Yang Zhou Ji-Ping Wang Ji-Ping Wang Nana Xin Nana Xin Shao-Zhen Nie Shao-Zhen Nie Chang-Qiu Zhao Chang-Qiu Zhao Li-Biao Han Li-Biao Han One-Pot Process That Efficiently Generates Single Stereoisomers of 1,3-Bisphosphinylpropanes Having Five Chiral Centers American Chemical Society 2015 KOH adduct stereoselective stereoselectively migration RP mechanism CentersP phosphorus Bisphosphinylpropane Chiral aldehydes 2 Efficiently Generates Single Stereoisomers bisphosphinylpropane stereogenic centers oxide yield room temperature 3. 2015-01-02 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/One_Pot_Process_That_Efficiently_Generates_Single_Stereoisomers_of_1_3_Bisphosphinylpropanes_Having_Five_Chiral_Centers/2220145 <i>P,C</i>-Stereogenic 1,3-bisphosphinylpropanes <b>3</b> that have up to five stereogenic centers could be obtained stereoselectively in high yields by a one-step reaction of (<i>R</i><sub>P</sub>)-menthylphenylphosphine oxide <b>1</b> with α,β-unsaturated aldehydes <b>2</b> catalyzed by KOH at room temperature. A mechanism was proposed as to involve a stereoselective intermolecular 1,3′-phosphorus migration from the 1,2-adduct of <b>1</b> with <b>2</b> to another <b>2</b> generating a 1,4-adduct that subsequently reacts with <b>1</b> to produce <b>3</b>.