%0 Generic %A Vicario, Javier %A Ortiz, Pablo %A Ezpeleta, José M. %A Palacios, Francisco %D 2015 %T Asymmetric Synthesis of Functionalized Tetrasubstituted α‑Aminophosphonates through Enantioselective Aza-Henry Reaction of Phosphorylated Ketimines %U https://acs.figshare.com/articles/dataset/Asymmetric_Synthesis_of_Functionalized_Tetrasubstituted_Aminophosphonates_through_Enantioselective_Aza_Henry_Reaction_of_Phosphorylated_Ketimines/2219743 %R 10.1021/jo502233m.s002 %2 https://acs.figshare.com/ndownloader/files/3855526 %K Enantioselective %K tetrasubstituted %K Catalytic %K nucleophilic addition %K aminophosphonic %K catalyze %K Tetrasubstituted %K ketimine %K acid %K enantiopure %K hydrogenation %K Aminophosphonate %K nitromethane %K Phosphorylated KetiminesBifunctional Cinchona alkaloid thioureas %K Asymmetric Synthesis %K Functionalized %K 3. %X Bifunctional Cinchona alkaloid thioureas efficiently catalyze asymmetric nucleophilic addition of nitromethane to ketimines derived from α-aminophosphonic acids to afford tetrasubstituted α-amino-β-nitro-phosphonates. Catalytic hydrogenation of (S)-α-amino-β-nitro-phosphonate 2d gives enantiopure (S)-α,β-diaminophosphonate 3. %I ACS Publications