%0 Generic
%A Vicario, Javier
%A Ortiz, Pablo
%A Ezpeleta, José M.
%A Palacios, Francisco
%D 2015
%T Asymmetric Synthesis of Functionalized
Tetrasubstituted
α‑Aminophosphonates through Enantioselective Aza-Henry
Reaction of Phosphorylated Ketimines
%U https://acs.figshare.com/articles/dataset/Asymmetric_Synthesis_of_Functionalized_Tetrasubstituted_Aminophosphonates_through_Enantioselective_Aza_Henry_Reaction_of_Phosphorylated_Ketimines/2219743
%R 10.1021/jo502233m.s002
%2 https://acs.figshare.com/ndownloader/files/3855526
%K Enantioselective
%K tetrasubstituted
%K Catalytic
%K nucleophilic addition
%K aminophosphonic
%K catalyze
%K Tetrasubstituted
%K ketimine
%K acid
%K enantiopure
%K hydrogenation
%K Aminophosphonate
%K nitromethane
%K Phosphorylated KetiminesBifunctional Cinchona alkaloid thioureas
%K Asymmetric Synthesis
%K Functionalized
%K 3.
%X Bifunctional Cinchona alkaloid thioureas efficiently
catalyze asymmetric nucleophilic addition of nitromethane to ketimines
derived from α-aminophosphonic acids to afford tetrasubstituted
α-amino-β-nitro-phosphonates. Catalytic hydrogenation
of (S)-α-amino-β-nitro-phosphonate 2d gives enantiopure (S)-α,β-diaminophosphonate 3.
%I ACS Publications