Microwave-Promoted Tin-Free Iminyl Radical Cyclization
with TEMPO Trapping: A Practical Synthesis of 2‑Acylpyrroles
Yu Cai
Ankur Jalan
Aaron R. Kubosumi
Steven L. Castle
10.1021/ol5035047.s001
https://acs.figshare.com/articles/journal_contribution/Microwave_Promoted_Tin_Free_Iminyl_Radical_Cyclization_with_TEMPO_Trapping_A_Practical_Synthesis_of_2_Acylpyrroles/2208733
Microwave-promoted
iminyl radical cyclizations can be terminated
by trapping with TEMPO, affording functionalized adducts. The use
of alkynes as radical acceptors delivers a range of 2-acylpyrroles
in good yields. Toxic and hazardous reagents, which are frequently
employed in radical reactions, are not required. The <i>O</i>-phenyl oxime ether substrates are constructed in a single step from
readily available ketones.
2015-02-06 00:00:00
Practical Synthesis
Cyclization
oxime
Iminyl
yield
Toxic
ether
cyclization
ketone
acylpyrrole
reagent
TEMPO Trapping
acceptor
substrate
Radical
alkyne
iminyl
functionalized adducts