Microwave-Promoted Tin-Free Iminyl Radical Cyclization with TEMPO Trapping: A Practical Synthesis of 2‑Acylpyrroles Yu Cai Ankur Jalan Aaron R. Kubosumi Steven L. Castle 10.1021/ol5035047.s001 https://acs.figshare.com/articles/journal_contribution/Microwave_Promoted_Tin_Free_Iminyl_Radical_Cyclization_with_TEMPO_Trapping_A_Practical_Synthesis_of_2_Acylpyrroles/2208733 Microwave-promoted iminyl radical cyclizations can be terminated by trapping with TEMPO, affording functionalized adducts. The use of alkynes as radical acceptors delivers a range of 2-acylpyrroles in good yields. Toxic and hazardous reagents, which are frequently employed in radical reactions, are not required. The <i>O</i>-phenyl oxime ether substrates are constructed in a single step from readily available ketones. 2015-02-06 00:00:00 Practical Synthesis Cyclization oxime Iminyl yield Toxic ether cyclization ketone acylpyrrole reagent TEMPO Trapping acceptor substrate Radical alkyne iminyl functionalized adducts