Saya, Jordy M. Vos, Klaas Kleinnijenhuis, Roel A. H. van Maarseveen, Jan Ingemann, Steen Hiemstra, Henk Total Synthesis of Aquatolide A total synthesis of the sesquiterpene lactone aquatolide has been accomplished. The central step is an intramolecular [2 + 2]-photocycloaddition of an allene onto an α,β-unsaturated δ-lactone. Other key steps are an intramolecular Horner–Wadsworth–Emmons reaction to close the lactone and an intramolecular Mukaiyama-type aldol reaction to cyclize the eight-membered ring. Racemic aquatolide has been resolved using preparative HPLC. intramolecular;sesquiterpene lactone aquatolide;HPLC;Total Synthesis;Racemic aquatolide 2015-08-07
    https://acs.figshare.com/articles/journal_contribution/Total_Synthesis_of_Aquatolide/2202565
10.1021/acs.orglett.5b01888.s001