10.1021/acs.orglett.5b02018.s001 Heeoon Han Heeoon Han Amos B. Smith Amos B. Smith Total Synthesis of (−)-Secu’amamine A Exploiting Type II Anion Relay Chemistry American Chemical Society 2015 Exploiting Type II Anion Relay Chemistry nitrogen skeleton stereochemical outcome flask functionality stereochemistry aza tricyclic core synthesis Type II Anion Relay Chemistry Secu rationale aldol reaction Total Synthesis ARC secu 2015-09-04 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Total_Synthesis_of_Secu_amamine_A_Exploiting_Type_II_Anion_Relay_Chemistry/2200360 A total synthesis of (−)-secu’amamine A has been achieved exploiting Type II Anion Relay Chemistry (ARC) to provide the full linear carbon and nitrogen skeleton in a single flask with the requisite stereochemistry and functionality. A mechanistic rationale is also proposed to account for the stereochemical outcome of the key aldol reaction leading to the advanced aza tricyclic core.