10.1021/ac504868w.s001 Muyi He Muyi He Zhenhua Xue Zhenhua Xue Yinna Zhang Yinna Zhang Zejian Huang Zejian Huang Xiang Fang Xiang Fang Feng Qu Feng Qu Zheng Ouyang Zheng Ouyang Wei Xu Wei Xu Development and Characterizations of a Miniature Capillary Electrophoresis Mass Spectrometry System American Chemical Society 2015 charge competition effects nanoelectrospray ionization pressure ionization sources DAPI Miniature Capillary Electrophoresis Mass Spectrometry SystemA MS instrument pressure interface isobaric peptides capillary electrophoresis mass spectrometry CE device MS system 2015-02-17 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Development_and_Characterizations_of_a_Miniature_Capillary_Electrophoresis_Mass_Spectrometry_System/2195401 A miniature capillary electrophoresis mass spectrometry (CE/MS) system has been developed in this work. A 100% electrical driven miniaturized CE device was integrated with a miniature MS instrument, which has a discontinuous atmospheric pressure interface (DAPI) for coupling with atmospheric pressure ionization sources. A nanoelectrospray ionization (nano-ESI) source was developed with a sheath liquid interface for coupling the miniature CE and the MS system. A systematic characterization and optimization of the analytical performance have been done. The analysis of isobaric peptides and avoiding charge competition effects in nano-ESI sources have been demonstrated.