10.1021/jo5029166.s001 Huijing Wang Huijing Wang Pei Tang Pei Tang Qilong Zhou Qilong Zhou Dan Zhang Dan Zhang Zhitao Chen Zhitao Chen Hongxiu Huang Hongxiu Huang Yong Qin Yong Qin One-Pot Synthesis of Multisubstituted Butyrolactonimidates: Total Synthesis of (−)-Nephrosteranic Acid American Chemical Society 2015 furan cascade reaction usefulness acid Butyrolactonimidate synthesis Multisubstituted hydroxylation Nephrosteranic intermediate imidate Synthesi butyrolactonimidate diester butyrolactone nephrosteranic chiral preparation AcidMultisubstituted stereoselective Michael addition Total cyclization 2015-03-06 00:00:00 Dataset https://acs.figshare.com/articles/dataset/One_Pot_Synthesis_of_Multisubstituted_Butyrolactonimidates_Total_Synthesis_of_Nephrosteranic_Acid/2189218 Multisubstituted chiral butyrolactonimidates have been synthesized via a one-pot, three-step cascade reaction in which (<i>R</i>)-<i>N</i>-<i>tert</i>-butanesulfinyl imidates and α,β-unsaturated diesters undergo highly stereoselective Michael addition, anion-oxidative hydroxylation, and cyclization. The synthesized butyrolactonimidates are versatile intermediates for preparation of substituted butyrolactones and furans. The usefulness of this cascade reaction is demonstrated through the concise total synthesis of natural product (−)-nephrosteranic acid.