%0 Journal Article
%A Petrelli, Riccardo
%A Torquati, Ilaria
%A Kachler, Sonja
%A Luongo, Livio
%A Maione, Sabatino
%A Franchetti, Palmarisa
%A Grifantini, Mario
%A Novellino, Ettore
%A Lavecchia, Antonio
%A Klotz, Karl-Norbert
%A Cappellacci, Loredana
%D 2015
%T 5′‑C‑Ethyl-tetrazolyl‑N6‑Substituted Adenosine and 2‑Chloro-adenosine
Derivatives as Highly Potent Dual Acting A1 Adenosine Receptor
Agonists and A3 Adenosine Receptor Antagonists
%U https://acs.figshare.com/articles/journal_contribution/5_i_C_i_Ethyl_tetrazolyl_i_N_i_sup_6_sup_Substituted_Adenosine_and_2_Chloro_adenosine_Derivatives_as_Highly_Potent_Dual_Acting_A_sub_1_sub_Adenosine_Receptor_Agonists_and_A_sub_3_sub_Adenosine_Receptor_Antagonists/2186725
%R 10.1021/acs.jmedchem.5b00074.s001
%2 https://acs.figshare.com/ndownloader/files/3820894
%K derivative
%K hA 3AR antagonists
%K hA 3AR recognition
%K hA 1AR agonists
%K selectivity profiles
%K 3 Adenosine Receptor AntagonistsA series
%K 1 Adenosine Receptor Agonists
%X A series
of N6-substituted-5′-C-(2-ethyl-2H-tetrazol-5-yl)-adenosine
and 2-chloro-adenosine derivatives was synthesized as novel, highly
potent dual acting hA1AR agonists and hA3AR
antagonists, potentially useful in the treatment of glaucoma and other
diseases. The best affinity and selectivity profiles were achieved
by N6-substitution with a 2-fluoro-4-chloro-phenyl-
or a methyl- group. Through an in silico receptor-driven approach,
the molecular bases of the hA1- and hA3AR recognition
and activation of this series of 5′-C-ethyl-tetrazolyl
derivatives were explained.
%I ACS Publications