10.1021/jp512212u.s001
Pritam Guha
Pritam
Guha
Biplab Roy
Biplab
Roy
Gourab Karmakar
Gourab
Karmakar
Prasant Nahak
Prasant
Nahak
Suraj Koirala
Suraj
Koirala
Manish Sapkota
Manish
Sapkota
Takeshi Misono
Takeshi
Misono
Kanjiro Torigoe
Kanjiro
Torigoe
Amiya Kumar Panda
Amiya Kumar
Panda
Ion-Pair
Amphiphile: A Neoteric Substitute That Modulates
the Physicochemical Properties of Biomimetic Membranes
American Chemical Society
2015
Thermal behavior
sodium dodecyl sulfate
hexadecyltrimethylammonium bromide
100 days
EE
HTMAB
scanning calorimetry
hydrodynamic diameter
hydrocarbon chain
vesicle
Such formulations
novel drug delivery systems
cationic dye methylene
MB
novel substitute
Physicochemical Properties
polydispersity index
solution behavior
IPA concentration
SLC
SDS
Entrapment efficiency
2015-03-19 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Ion_Pair_Amphiphile_A_Neoteric_Substitute_That_Modulates_the_Physicochemical_Properties_of_Biomimetic_Membranes/2184871
Ion-pair amphiphiles (IPAs) are neoteric
pseudo-double-tailed compounds
with potential as a novel substitute of phospholipid. IPA, synthesized
by stoichiometric/equimolar mixing of aqueous solution of hexadecyltrimethylammonium
bromide (HTMAB) and sodium dodecyl sulfate (SDS), was used as a potential
substituent of naturally occurring phospholipid, soylecithin (SLC).
Vesicles were prepared using SLC and IPA in different ratios along
with cholesterol. The impact of IPA on SLC was examined by way of
surface pressure (π)–area (<i>A</i>) measurements.
Associated thermodynamic parameters were evaluated; interfacial miscibility
between the components was found to depend on SLC/IPA ratio. Solution
behavior of the bilayers, in the form of vesicles, was investigated
by monitoring the hydrodynamic diameter, zeta potential, and polydispersity
index over a period of 100 days. Size and morphology of the vesicles
were also investigated by electron microscopic studies. Systems comprising
20 and 40 mol % IPA exhibited anomalous behavior. Thermal behavior
of the vesicles, as scrutinized by differential scanning calorimetry,
was correlated with the hydrocarbon chain as well as the headgroup
packing. Entrapment efficiency (EE) of the vesicles toward the cationic
dye methylene blue (MB) was also evaluated. Vesicles were smart enough
to entrap the dye, and the efficiency was found to vary with IPA concentration.
EE was found to be well above 80% for some stable dispersions. Such
formulations thus could be considered to have potential as novel drug
delivery systems.