10.1021/acs.orglett.5b00479.s002 Lin Huang Lin Huang Sheng-Cai Zheng Sheng-Cai Zheng Bin Tan Bin Tan Xin-Yuan Liu Xin-Yuan Liu Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes American Chemical Society 2015 alkene CF 3 source Radical Trifluoromethylation reaction exhibits substrate scope functionality tolerance 2015-03-20 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Metal_Free_Direct_1_6_and_1_2_Difunctionalization_Triggered_by_Radical_Trifluoromethylation_of_Alkenes/2184535 A metal-free direct remote C–H functionalization triggered by radical trifluoromethylation of alkenes was explored, realizing highly selective 1,6-difunctionalization of alkenes toward valuable trifluoromethyl α-hydroxycarbonyl compounds. Furthermore, a metal-free direct intermolecular regioselective 1,2-oxytrifluoromethylation of alkenes is also disclosed. With Togni’s reagent as both the CF<sub>3</sub> source and oxidant, the reaction exhibits a broad substrate scope with excellent functionality tolerance under mild metal-free conditions, thus showing great potential for synthetic utility.