10.1021/acs.orglett.5b00479.s002
Lin Huang
Lin
Huang
Sheng-Cai Zheng
Sheng-Cai
Zheng
Bin Tan
Bin
Tan
Xin-Yuan Liu
Xin-Yuan
Liu
Metal-Free Direct 1,6- and 1,2-Difunctionalization
Triggered by Radical Trifluoromethylation of Alkenes
American Chemical Society
2015
alkene
CF 3 source
Radical Trifluoromethylation
reaction exhibits
substrate scope
functionality tolerance
2015-03-20 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Metal_Free_Direct_1_6_and_1_2_Difunctionalization_Triggered_by_Radical_Trifluoromethylation_of_Alkenes/2184535
A metal-free direct remote C–H
functionalization triggered
by radical trifluoromethylation of alkenes was explored, realizing
highly selective 1,6-difunctionalization of alkenes toward valuable
trifluoromethyl α-hydroxycarbonyl compounds. Furthermore, a
metal-free direct intermolecular regioselective 1,2-oxytrifluoromethylation
of alkenes is also disclosed. With Togni’s reagent as both
the CF<sub>3</sub> source and oxidant, the reaction exhibits a broad
substrate scope with excellent functionality tolerance under mild
metal-free conditions, thus showing great potential for synthetic
utility.