%0 Generic %A Yang, Xiao-Fei %A Hu, Xu-Hong %A Loh, Teck-Peng %D 2015 %T Expedient Synthesis of Pyrroloquinolinones by Rh-Catalyzed Annulation of N‑Carbamoyl Indolines with Alkynes through a Directed C–H Functionalization/C–N Cleavage Sequence %U https://acs.figshare.com/articles/dataset/Expedient_Synthesis_of_Pyrroloquinolinones_by_Rh_Catalyzed_Annulation_of_i_N_i_Carbamoyl_Indolines_with_Alkynes_through_a_Directed_C_H_Functionalization_C_N_Cleavage_Sequence/2184442 %R 10.1021/acs.orglett.5b00355.s004 %2 https://acs.figshare.com/ndownloader/files/3818608 %K Indoline %K Annulation %K selectivity %K Expedient Synthesis %K Functionalization %K analogue %K indoline %K sequential cleavage %K Pyrroloquinolinone %K strategy %K functionalization %K SequenceA %K Alkyne %K efficiency %K pyrrolo %K Cleavage %K alkyne %K urea motif %K alkenylation %K bond %X A Rh-catalyzed redox-neutral C–H functionalization of N-carbamoyl indolines with various internal alkynes has been developed. The reaction, which involves the sequential cleavage of the C–H bond of the indoline at the C7-position and the C–N bond of the urea motif, provides a divergent protocol to rapidly assemble fused-ring pyrrolo­quinolinone analogues by using a direct alkenylation/annulation strategy with high efficiency and selectivity. %I ACS Publications