%0 Generic
%A Yang, Xiao-Fei
%A Hu, Xu-Hong
%A Loh, Teck-Peng
%D 2015
%T Expedient Synthesis of Pyrroloquinolinones by Rh-Catalyzed
Annulation of N‑Carbamoyl Indolines with Alkynes
through a Directed C–H Functionalization/C–N Cleavage
Sequence
%U https://acs.figshare.com/articles/dataset/Expedient_Synthesis_of_Pyrroloquinolinones_by_Rh_Catalyzed_Annulation_of_i_N_i_Carbamoyl_Indolines_with_Alkynes_through_a_Directed_C_H_Functionalization_C_N_Cleavage_Sequence/2184442
%R 10.1021/acs.orglett.5b00355.s004
%2 https://acs.figshare.com/ndownloader/files/3818608
%K Indoline
%K Annulation
%K selectivity
%K Expedient Synthesis
%K Functionalization
%K analogue
%K indoline
%K sequential cleavage
%K Pyrroloquinolinone
%K strategy
%K functionalization
%K SequenceA
%K Alkyne
%K efficiency
%K pyrrolo
%K Cleavage
%K alkyne
%K urea motif
%K alkenylation
%K bond
%X A Rh-catalyzed redox-neutral C–H
functionalization of N-carbamoyl indolines with various
internal alkynes has
been developed. The reaction, which involves the sequential cleavage
of the C–H bond of the indoline at the C7-position and the
C–N bond of the urea motif, provides a divergent protocol to
rapidly assemble fused-ring pyrroloquinolinone analogues by
using a direct alkenylation/annulation strategy with high efficiency
and selectivity.
%I ACS Publications