10.1021/acs.orglett.5b00355.s004
Xiao-Fei Yang
Xiao-Fei
Yang
Xu-Hong Hu
Xu-Hong
Hu
Teck-Peng Loh
Teck-Peng
Loh
Expedient Synthesis of Pyrroloquinolinones by Rh-Catalyzed
Annulation of <i>N</i>‑Carbamoyl Indolines with Alkynes
through a Directed C–H Functionalization/C–N Cleavage
Sequence
American Chemical Society
2015
Indoline
Annulation
selectivity
Expedient Synthesis
Functionalization
analogue
indoline
sequential cleavage
Pyrroloquinolinone
strategy
functionalization
SequenceA
Alkyne
efficiency
pyrrolo
Cleavage
alkyne
urea motif
alkenylation
bond
2015-03-20 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Expedient_Synthesis_of_Pyrroloquinolinones_by_Rh_Catalyzed_Annulation_of_i_N_i_Carbamoyl_Indolines_with_Alkynes_through_a_Directed_C_H_Functionalization_C_N_Cleavage_Sequence/2184442
A Rh-catalyzed redox-neutral C–H
functionalization of <i>N</i>-carbamoyl indolines with various
internal alkynes has
been developed. The reaction, which involves the sequential cleavage
of the C–H bond of the indoline at the C7-position and the
C–N bond of the urea motif, provides a divergent protocol to
rapidly assemble fused-ring pyrroloquinolinone analogues by
using a direct alkenylation/annulation strategy with high efficiency
and selectivity.