10.1021/acs.orglett.5b00355.s004 Xiao-Fei Yang Xiao-Fei Yang Xu-Hong Hu Xu-Hong Hu Teck-Peng Loh Teck-Peng Loh Expedient Synthesis of Pyrroloquinolinones by Rh-Catalyzed Annulation of <i>N</i>‑Carbamoyl Indolines with Alkynes through a Directed C–H Functionalization/C–N Cleavage Sequence American Chemical Society 2015 Indoline Annulation selectivity Expedient Synthesis Functionalization analogue indoline sequential cleavage Pyrroloquinolinone strategy functionalization SequenceA Alkyne efficiency pyrrolo Cleavage alkyne urea motif alkenylation bond 2015-03-20 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Expedient_Synthesis_of_Pyrroloquinolinones_by_Rh_Catalyzed_Annulation_of_i_N_i_Carbamoyl_Indolines_with_Alkynes_through_a_Directed_C_H_Functionalization_C_N_Cleavage_Sequence/2184442 A Rh-catalyzed redox-neutral C–H functionalization of <i>N</i>-carbamoyl indolines with various internal alkynes has been developed. The reaction, which involves the sequential cleavage of the C–H bond of the indoline at the C7-position and the C–N bond of the urea motif, provides a divergent protocol to rapidly assemble fused-ring pyrrolo­quinolinone analogues by using a direct alkenylation/annulation strategy with high efficiency and selectivity.