Palladium-Catalyzed Intramolecular Aminoacetoxylation of Unactivated Alkenes with Hydrogen Peroxide as Oxidant Haitao Zhu Pinhong Chen Guosheng Liu 10.1021/acs.orglett.5b00373.s002 https://acs.figshare.com/articles/dataset/Palladium_Catalyzed_Intramolecular_Aminoacetoxylation_of_Unactivated_Alkenes_with_Hydrogen_Peroxide_as_Oxidant/2184433 A palladium-catalyzed intramolecular aminoacetoxylation of unactivated alkenes was developed in which H<sub>2</sub>O<sub>2</sub> was used as the sole oxidant. A variety of 3-acetoxylated piperidines were obtained in good yields with good to excellent regio- and diastereoselectivities. Mechanistic study revealed that the addition of di­(2-pyridyl) ketone (dpk) ligand was crucial to promote the oxidative cleavage of the C–Pd­(II) bond by H<sub>2</sub>O<sub>2</sub> to give the C–OAc bond. 2015-03-20 00:00:00 acetoxylated diastereoselectivitie Aminoacetoxylation oxidative intramolecular OxidantA Alkene piperidine aminoacetoxylation ligand variety Mechanistic Unactivated alkene H 2O di Peroxide regio oxidant unactivated dpk yield ketone Intramolecular cleavage bond