Zhang, Lei Liu, Honglei Qiao, Guanyu Hou, Zhanfeng Liu, Yang Xiao, Yumei Guo, Hongchao Phosphine-Catalyzed Highly Enantioselective [3 + 3] Cycloaddition of Morita–Baylis–Hillman Carbonates with C,N-Cyclic Azomethine Imines The first phosphine-catalyzed highly enantioselective [3 + 3] cycloaddition of Morita–Baylis–Hillman carbonates with C,N-cyclic azomethine imines is described. Using a spirocyclic chiral phosphine as the catalyst, a novel class of pharmaceutically interesting 4,6,7,11b-tetrahydro-1<i>H</i>-pyridazino­[6,1-<i>a</i>]­iso-quinoline derivatives were obtained in high yields with good to excellent diastereoselectivities and extremely excellent enantioselectivities (98–>99% ee). spirocyclic chiral phosphine;Enantioselective;diastereoselectivitie;ee;Carbonate;cycloaddition;derivative;enantioselective;IminesThe;imine;pharmaceutically;Azomethine;enantioselectivitie;novel class;catalyst;carbonates;azomethine;yield;Morita;Cycloaddition 2015-04-08
    https://acs.figshare.com/articles/journal_contribution/Phosphine_Catalyzed_Highly_Enantioselective_3_3_Cycloaddition_of_Morita_Baylis_Hillman_Carbonates_with_C_N_Cyclic_Azomethine_Imines/2178712
10.1021/jacs.5b01138.s001