10.1021/jacs.5b01138.s003 Lei Zhang Lei Zhang Honglei Liu Honglei Liu Guanyu Qiao Guanyu Qiao Zhanfeng Hou Zhanfeng Hou Yang Liu Yang Liu Yumei Xiao Yumei Xiao Hongchao Guo Hongchao Guo Phosphine-Catalyzed Highly Enantioselective [3 + 3] Cycloaddition of Morita–Baylis–Hillman Carbonates with C,N-Cyclic Azomethine Imines American Chemical Society 2015 spirocyclic chiral phosphine Enantioselective diastereoselectivitie ee Carbonate cycloaddition derivative enantioselective IminesThe imine pharmaceutically Azomethine enantioselectivitie novel class catalyst carbonates azomethine yield Morita Cycloaddition 2015-04-08 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Phosphine_Catalyzed_Highly_Enantioselective_3_3_Cycloaddition_of_Morita_Baylis_Hillman_Carbonates_with_C_N_Cyclic_Azomethine_Imines/2178703 The first phosphine-catalyzed highly enantioselective [3 + 3] cycloaddition of Morita–Baylis–Hillman carbonates with C,N-cyclic azomethine imines is described. Using a spirocyclic chiral phosphine as the catalyst, a novel class of pharmaceutically interesting 4,6,7,11b-tetrahydro-1<i>H</i>-pyridazino­[6,1-<i>a</i>]­iso-quinoline derivatives were obtained in high yields with good to excellent diastereoselectivities and extremely excellent enantioselectivities (98–>99% ee).