10.1021/jacs.5b01138.s003
Lei Zhang
Lei
Zhang
Honglei Liu
Honglei
Liu
Guanyu Qiao
Guanyu
Qiao
Zhanfeng Hou
Zhanfeng
Hou
Yang Liu
Yang
Liu
Yumei Xiao
Yumei
Xiao
Hongchao Guo
Hongchao
Guo
Phosphine-Catalyzed
Highly Enantioselective [3 + 3]
Cycloaddition of Morita–Baylis–Hillman Carbonates with
C,N-Cyclic Azomethine Imines
American Chemical Society
2015
spirocyclic chiral phosphine
Enantioselective
diastereoselectivitie
ee
Carbonate
cycloaddition
derivative
enantioselective
IminesThe
imine
pharmaceutically
Azomethine
enantioselectivitie
novel class
catalyst
carbonates
azomethine
yield
Morita
Cycloaddition
2015-04-08 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Phosphine_Catalyzed_Highly_Enantioselective_3_3_Cycloaddition_of_Morita_Baylis_Hillman_Carbonates_with_C_N_Cyclic_Azomethine_Imines/2178703
The first phosphine-catalyzed highly
enantioselective [3 + 3] cycloaddition
of Morita–Baylis–Hillman carbonates with C,N-cyclic
azomethine imines is described. Using a spirocyclic chiral phosphine
as the catalyst, a novel class of pharmaceutically interesting 4,6,7,11b-tetrahydro-1<i>H</i>-pyridazino[6,1-<i>a</i>]iso-quinoline
derivatives were obtained in high yields with good to excellent diastereoselectivities
and extremely excellent enantioselectivities (98–>99% ee).