10.1021/jacs.5b02212.s002 Zi-Qiang Rong Zi-Qiang Rong Yao Zhang Yao Zhang Raymond Hong Bing Chua Raymond Hong Bing Chua Hui-Jie Pan Hui-Jie Pan Yu Zhao Yu Zhao Dynamic Kinetic Asymmetric Amination of Alcohols: From A Mixture of Four Isomers to Diastereo- and Enantiopure α‑Branched Amines American Chemical Society 2015 Dynamic Kinetic Asymmetric Amination borrowing hydrogen methodology diastereo chiral phosphoric acid enantiopure amines orthogonal mechanisms 2015-04-22 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Dynamic_Kinetic_Asymmetric_Amination_of_Alcohols_From_A_Mixture_of_Four_Isomers_to_Diastereo_and_Enantiopure_Branched_Amines/2174290 The first dynamic kinetic asymmetric amination of alcohols via borrowing hydrogen methodology is presented. Under the cooperative catalysis by an iridium complex and a chiral phosphoric acid, α-branched alcohols that exist as a mixture of four isomers undergo racemization by two orthogonal mechanisms and are converted to diastereo- and enantiopure amines bearing adjacent stereocenters. The preparation of diastereo- and enantiopure 1,2-amino alcohols is also realized using this catalytic system.