10.1021/jacs.5b02212.s002
Zi-Qiang Rong
Zi-Qiang
Rong
Yao Zhang
Yao
Zhang
Raymond Hong Bing Chua
Raymond
Hong Bing Chua
Hui-Jie Pan
Hui-Jie
Pan
Yu Zhao
Yu
Zhao
Dynamic
Kinetic Asymmetric Amination of Alcohols:
From A Mixture of Four Isomers to Diastereo- and Enantiopure α‑Branched
Amines
American Chemical Society
2015
Dynamic Kinetic Asymmetric Amination
borrowing hydrogen methodology
diastereo
chiral phosphoric acid
enantiopure amines
orthogonal mechanisms
2015-04-22 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Dynamic_Kinetic_Asymmetric_Amination_of_Alcohols_From_A_Mixture_of_Four_Isomers_to_Diastereo_and_Enantiopure_Branched_Amines/2174290
The
first dynamic kinetic asymmetric amination of alcohols via
borrowing hydrogen methodology is presented. Under the cooperative
catalysis by an iridium complex and a chiral phosphoric acid, α-branched
alcohols that exist as a mixture of four isomers undergo racemization
by two orthogonal mechanisms and are converted to diastereo- and enantiopure
amines bearing adjacent stereocenters. The preparation of diastereo-
and enantiopure 1,2-amino alcohols is also realized using this catalytic
system.