10.1021/jacs.5b01707.s002
Jun Zheng
Jun
Zheng
Shao-Bo Wang
Shao-Bo
Wang
Chao Zheng
Chao
Zheng
Shu-Li You
Shu-Li
You
Asymmetric Dearomatization of Naphthols via a Rh-Catalyzed
C(sp<sup>2</sup>)–H Functionalization/Annulation Reaction
American Chemical Society
2015
enantioenriched spirocyclic enones
presence
Functionalization
stereogenic
enantioselective
quaternary
functionalization
Naphthol
yield
ReactionA
catalyst
oxidant
center
chiral
Asymmetric Dearomatization
dearomatization
alkyne
aryl
Cp
Cu
2015-04-22 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Asymmetric_Dearomatization_of_Naphthols_via_a_Rh_Catalyzed_C_sp_sup_2_sup_H_Functionalization_Annulation_Reaction/2174257
A Rh-catalyzed enantioselective dearomatization
of 1-aryl-2-naphthols with internal alkynes via C–H functionalization
reaction was achieved. In the presence of a chiral Cp/Rh catalyst
and combined oxidants of Cu(OAc)<sub>2</sub> and air (oxygen), various
highly enantioenriched spirocyclic enones bearing an all-carbon quaternary
stereogenic center could be synthesized in 33–98% yields with
up to 97:3 er.