Regioselectivity of the C‑Metalation of 6‑Furylpurine: Importance of Directing Effects SinhaIndranil HeppAlexander SchirmerBirgitta KöstersJutta NeugebauerJohannes MüllerJens 2015 We report the C-metalation of 6-furylpurine with Pt<sup>2+</sup>, Pd<sup>2+</sup>, and Hg<sup>2+</sup>. The ligand binds the metal ions in a bidentate fashion, involving the N7 purine atom and one of the furyl carbon atoms. The regioselectivity is determined by the metal ion. Pt<sup>2+</sup> and Pd<sup>2+</sup> coordinate the furyl moiety in its β position and Hg<sup>2+</sup> in its electronically preferred α position.