10.1021/jacs.5b00795.s001
Xuyu Tan
Xuyu
Tan
Ben B. Li
Ben B.
Li
Xueguang Lu
Xueguang
Lu
Fei Jia
Fei
Jia
Clarissa Santori
Clarissa
Santori
Priyanka Menon
Priyanka
Menon
Hui Li
Hui
Li
Bohan Zhang
Bohan
Zhang
Jean J. Zhao
Jean J.
Zhao
Ke Zhang
Ke
Zhang
Light-Triggered,
Self-Immolative Nucleic Acid-Drug
Nanostructures
American Chemical Society
2015
cancer cells
acid shell
payload molecules
model drug
DNA
light activation
drug molecules
molecule fragments
prodrug molecules
intracellular delivery
carrier systems
nanostructures exhibit
2015-05-20 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Light_Triggered_Self_Immolative_Nucleic_Acid_Drug_Nanostructures/2165230
The
simultaneous intracellular delivery of multiple types of payloads,
such as hydrophobic drugs and nucleic acids, typically requires complex
carrier systems. Herein, we demonstrate a self-deliverable form of
nucleic acid–drug nanostructure that is composed almost entirely
of payload molecules. Upon light activation, the nanostructure sheds
the nucleic acid shell, while the core, which consists of prodrug
molecules, disintegrates via an irreversible self-immolative process,
releasing free drug molecules and small molecule fragments. We demonstrate
that the nanostructures exhibit enhanced stability against DNase I
compared with free DNA, and that the model drug (camptothecin) released
exhibits similar efficacy as free, unmodified drugs toward cancer
cells.