10.1021/np500836y.s002 Xuemei Liu Xuemei Liu Karla Frydenvang Karla Frydenvang Huizhen Liu Huizhen Liu Lin Zhai Lin Zhai Ming Chen Ming Chen Carl Erik Olsen Carl Erik Olsen Søren Brøgger Christensen Søren Brøgger Christensen Iminolactones from <i>Schizophyllum commune</i> American Chemical Society 2015 cancer cells compound acid phenylalanine alkaloids fruiting bodies Schizophyllym commune biosynthesi moiety acid precursor carboxyl group Iminolactone inhibition derivative tryptophan iminolactone Schizophyllum communeSchizines principle oxazinone hydroxy dihydro 2015-05-22 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Iminolactones_from_i_Schizophyllum_commune_i_/2164666 Schizines A (<b>1</b>) and B (<b>2</b>), the first naturally occurring iminolactones (3,6-dihydro-2<i>H</i>-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of <i>Schizophyllym commune</i>. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.