10.1021/np500836y.s002
Xuemei Liu
Xuemei
Liu
Karla Frydenvang
Karla
Frydenvang
Huizhen Liu
Huizhen
Liu
Lin Zhai
Lin
Zhai
Ming Chen
Ming
Chen
Carl Erik Olsen
Carl Erik
Olsen
Søren Brøgger Christensen
Søren Brøgger
Christensen
Iminolactones
from <i>Schizophyllum commune</i>
American Chemical Society
2015
cancer cells
compound
acid phenylalanine
alkaloids
fruiting bodies
Schizophyllym commune
biosynthesi
moiety
acid precursor
carboxyl group
Iminolactone
inhibition
derivative
tryptophan
iminolactone
Schizophyllum communeSchizines
principle
oxazinone
hydroxy
dihydro
2015-05-22 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Iminolactones_from_i_Schizophyllum_commune_i_/2164666
Schizines A (<b>1</b>) and
B (<b>2</b>), the first
naturally occurring iminolactones (3,6-dihydro-2<i>H</i>-1,4-oxazin-2-one derivatives) to be reported, have been isolated
from the fruiting bodies of <i>Schizophyllym commune</i>. In principle the 2-oxazinone moiety might have been formed by a
reaction between the amino acid phenylalanine or tryptophan and an
2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that
the carboxyl group of the amino acid precursor is preserved during
the biosynthesis. The compounds showed some inhibition of the growth
of cancer cells.