10.1021/om501208x.s001
James
P. Hall
James
P.
Hall
Hanna Beer
Hanna
Beer
Katrin Buchner
Katrin
Buchner
David J. Cardin
David J.
Cardin
Christine J. Cardin
Christine J.
Cardin
The Structural Effect of Methyl Substitution on the Binding of Polypyridyl Ru–dppz
Complexes to DNA
American Chemical Society
2015
Ru
synthesis
TAP
DNA binding
derivative
DNAPolypyridyl ruthenium complexes
2015-06-08 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/The_Structural_Effect_of_Methyl_Substitution_on_the_Binding_of_Polypyridyl_Ru_dppz_Complexes_to_DNA/2160544
Polypyridyl
ruthenium complexes have been intensively studied and
possess photophysical properties that are both interesting and useful.
They can act as probes for DNA, with a substantial enhancement in
emission when bound, and can induce DNA damage upon photoirradiation.
Therefore, the synthesis and characterization of DNA binding of new
complexes is an area of intense research activity. While knowledge
of how the binding of derivatives compares to that of the parent compound
is highly desirable, this information can be difficult to obtain.
Here we report the synthesis of three new methylated complexes, [Ru(TAP)<sub>2</sub>(dppz-10-Me)]Cl<sub>2</sub>, [Ru(TAP)<sub>2</sub>(dppz-10,12-Me<sub>2</sub>)]Cl<sub>2</sub>, and [Ru(TAP)<sub>2</sub>(dppz-11-Me)]Cl<sub>2</sub> (TAP = 1,4,5,8-tetraazaphenanthrene; dppz = dipyrido[3,2-<i>a</i>:2′,3′-<i>c</i>]phenazine), and
examine the consequences for DNA binding through the use of atomic-resolution
X-ray crystallography. We find that the methyl groups are located
in discrete positions with a complete directional preference. This
may help to explain the quenching behavior found in solution for analogous
[Ru(phen)<sub>2</sub>(dppz)]<sup>2+</sup> derivatives.